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What is DMT?

Dimethyltryptamine, commonly known as DMT, is a naturally occurring tryptamine compound found in a wide range of plants and animals, and it is also produced endogenously in the human body in trace amounts. Structurally, it is closely related to serotonin, which explains much of its activity in the central nervous system. It is one of the most potent psychedelic compounds known to science, active at doses measured in milligrams rather than grams.

Dimethyltryptamine has been the subject of scientific curiosity for decades, and in recent years it has moved from the margins of psychopharmacology into formal clinical research, with studies exploring its potential in treatment-resistant depression and other conditions. This article provides an overview of what dimethyltryptamine is, how it works, how it is traditionally used, and what the current research landscape looks like.